altered mitochondrial response to activation of t-cells in neonate

Altered mitochondrial response to activation of T-cells in neonate.

UNLABELLED Mitochondrial functions have a major impact on T-cell functionality. In this study we characterized whether mitochondrial function in the neonatal T-cells differs from that in the adult T-cells during short T-cell activation. METHODS We used flow cytometry methods to test mitochondrial mass and to monitor mitochondrial Ca²⁺ levels, mitochondrial potential and superoxide generation ...

Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes

Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...

Activation-Induced Apoptosis in T cells: Effect of Age and Caloric Restriction

We have previously shown that the proliferative response of T cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (CR) attenuated the age-related decline in proliferation and IL-2 expression. Because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...

Evaluation of Troponin-T level in Neonate with Mechanical Ventilation

Introduction: Troponin- T is the best biological marker of heart injuries, that isn’t affected by sex, age, birth weight and gestational age. Myocardial damage in infancy is a risk factor eventual cardiac disease. This study carried out for cardiac evaluation of neonates with mechanical ventilation by Troponin T. Methods: This case-control study carried out on 60 infants that were admitte...

Influenza Virus Is Altered in Neonatal Mice The Migration of T Cells in Response to

Imaging immune response in vivo: cytolytic action of genetically altered T cells directed to glioblastoma multiforme.

PURPOSE Clinical trials have commenced to evaluate the feasibility of targeting malignant gliomas with genetically engineered CTLs delivered directly to the tumor bed in the central nervous system. The objective of this study is to determine a suite of magnetic resonance imaging (MRI) measurements using an orthotopic xenograft murine model that can noninvasively monitor immunologically mediated...